Biography
In his research, Corvera focuses on the mechanisms that underlie inflammation, thickening and scarring in the biliary tract.
Corvera graduated from the University of California, San Diego School of Medicine. He completed a residency in general surgery at UCSF. At Memorial Sloan Kettering Cancer Center in New York City, he completed a clinical fellowship in surgical oncology as well as a fellowship in hepatobiliary surgery.
Videos
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Memorial Sloan Kettering Cancer Center, New York | Hepatobiliary Surgery | Surgery | 2002 |
Memorial Sloan Kettering Cancer Center , New York | Surgical Oncology Clinical Fellowship | Surgery | 2001 |
University of California, San Francisco | General Surgery Residency | School of Medicine | 2000 |
University of California San Diego | M.D. | School of Medicine | 1993 |
Board Certifications
- American Board of Surgery
Clinical Expertise
Ascites
Bile Duct Injuries
Bile Duct Strictures
Bile Duct Cancer (Cholangiocarcinoma)
Gastrointestinal Carcinoid Tumor
Gastrointestinal Stromal Tumor (GIST)
Choledochal Cysts
Portal Hypertension
Liver Cancer (Hepatocellular Carcinoma)
Minimally Invasive Liver & Pancreas Surgery
Melanoma
Pancreatic Cancer
Pancreatic Cysts
Soft Tissue Sarcomas
Liver Cysts
Liver Metastases
Gallbladder Cancer
Stomach (Gastric) Cancer
Pancreatic Neuroendocrine (Islet Cell) Tumors
Bridging Therapies to Downstage HCC in Setting of Liver Transplantation
Program Affiliations
Hepatobiliary and Pancreas Surgery Program
UCSF Helen Diller Family Comprehensive Cancer Center
UCSF Department of Surgery at the San Francisco VA
Research Narrative
Dr. Corvera's scientific research interest is focused on understanding the mechanisms of biliary tract fibrosis and inflammation. More specifically, he is interested in studying the clinical consequences of biliary fibrosis-- mainly cholestatisis. Cholestasis is characterized by impaired bile flow causing a high concentration of bile acids in the liver and the circulation. Prolonged exposure to bile acids in the liver can progress to end-stage liver disease and cirrhosis. In the gastrointestinal tract, the absence of bile flow causes profound local and systemic metabolic disturbances. Dr.Corvera is actively investigating the role of a novel cell surface receptor specific for bile acids that may play a critical role in normal and disease states.
Research Interests
Proteases and Proteinase Activated Receptors in the Biliary Tract
Publications
- ASO Visual Abstract: Distinct Indications for Adjuvant Therapy in Resected Invasive Mucinous Cystic Neoplasms of the Pancreas Compared with Pancreatic Ductal Adenocarcinoma.| | PubMed
- Adult Pancreatoblastoma: Clinical Insights and Outcomes Compared to Pancreatic Ductal Adenocarcinoma (PDAC).| | PubMed
- Prognostic implications of margin status in association with systemic treatment in a cohort study of patients with resection of colorectal liver metastases.| | PubMed
- Graft choice in pancreatectomy with vascular resection: equivalent safety in selected patients.| | PubMed
- Resection versus resection with ablation: Analysis from the colorectal liver operative metastasis international collaborative.| | PubMed
- ASO Visual Abstract: Long-Duration Neoadjuvant Therapy with FOLFIRINOX Yields Favorable Outcomes for Patients Who Undergo Surgery for Pancreatic Cancer.| | PubMed
- Distinct Indications for Adjuvant Therapy in Resected Invasive Mucinous Cystic Neoplasms of the Pancreas Compared with Pancreatic Ductal Adenocarcinoma.| | PubMed
- Minimal Residual Disease using a Plasma-Only Circulating Tumor DNA Assay to Predict Recurrence of Metastatic Colorectal Cancer Following Curative Intent Treatment.| | PubMed
- Long-Duration Neoadjuvant Therapy with FOLFIRINOX Yields Favorable Outcomes for Patients Who Undergo Surgery for Pancreatic Cancer.| | PubMed
- Long-Term Survival Outcomes After Minimally Invasive Surgery for Ileal Neuroendocrine Tumors.| | PubMed
- National practice patterns in the use of endoscopic ultrasound biopsy for resectable Pancreatic Neuroendocrine Tumors: Insights into the role of DOTATATE PET/CT in diagnosis.| | PubMed
- Recurrence and tumor-related death after resection of hepatocellular carcinoma in patients with metabolic syndrome.| | PubMed
- Metastatic melanoma to small bowel: metastasectomy is supported in the era of immunotherapy and checkpoint inhibitors.| | PubMed
- Portal Vein Thrombosis After Transarterial Embolization for Hepatocellular Carcinoma.| | PubMed
- Intraoperative hepatic artery infusion pump perfusion testing with indocyanine green near-infrared imaging offers multiple potential advantages.| | PubMed
- Improved survival of patients receiving immunotherapy and chemotherapy following curative-intent resection of colorectal liver metastases.| | PubMed
- A Machine Learning Approach to Predict Postoperative Pancreatic Fistula After Pancreaticoduodenectomy Using Only Preoperatively Known Data.| | PubMed
- ASO Visual Abstract: National Practice Patterns in Malignant Peritoneal Mesothelioma-Updates in Management and Survival.| | PubMed
- National Practice Patterns in Malignant Peritoneal Mesothelioma: Updates in Management and Survival.| | PubMed
- Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.| | PubMed
- Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.| | PubMed
- Minimally Invasive Versus Open Liver Resections for Hepatocellular Carcinoma in Patients With Metabolic Syndrome.| | PubMed
- Conditional Survival After Hepatectomy for Colorectal Liver Metastasis: Results from the Colorectal Liver Operative Metastasis International Collaborative (COLOMIC).| | PubMed
- Survival Outcomes of Optimally Treated Colorectal Metastases: The Importance of R0 Status in Surgical Treatment of Hepatic and Peritoneal Surface Disease.| | PubMed
- Machine Learning Models for Predicting the Outcomes of Surgical Treatment of Colorectal Liver Metastases.| | PubMed
- Hypertension Requiring Medication Use: a Silent Predictor of Poor Outcomes After Pancreaticoduodenectomy.| | PubMed
- Model to predict major complications following liver resection for HCC in patients with metabolic syndrome.| | PubMed
- Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States.| | PubMed
- Hand-Assisted Versus Pure Minimally-Invasive Distal Pancreatectomy: Is There a Downside to Lending a Hand?| | PubMed
- Minimally Invasive Distal Pancreatectomy Techniques: A Contemporary Analysis Exploring Trends, Similarities, and Differences to Open Surgery.| | PubMed
- Outcomes after repeat hepatectomy for colorectal liver metastases from the colorectal liver operative metastasis international collaborative (COLOMIC).| | PubMed
- Primary Cutaneous Malignant Perivascular Epithelioid Cell Tumor Mimicking Undifferentiated Pleomorphic Sarcoma: A Report of a Rare Entity.| | PubMed
- Perioperative chemotherapy for resectable colorectal liver metastases: Analysis from the Colorectal Operative Liver Metastases International Collaborative (COLOMIC).| | PubMed
- Association of primary tumor laterality with surgical outcomes for colorectal liver metastases: results from the Colorectal Liver Operative Metastasis International Collaborative (COLOMIC).| | PubMed
- ASO Visual Abstract: Determining Hospital Volume Threshold for the Safety of Minimally Invasive Pancreaticoduodenectomy: A Contemporary Cutpoint Analysis.| | PubMed
- Determining Hospital Volume Threshold for Safety of Minimally Invasive Pancreaticoduodenectomy: A Contemporary Cutpoint Analysis.| | PubMed
- Multifocal pancreatic PPoma in the setting of MEN1: Case report and review of literature.| | PubMed
- Burden of Ionizing Radiation in the Diagnosis and Management of Necrotizing Pancreatitis.| | PubMed
- Minimally Invasive Surgery for Ileal Neuroendocrine Tumors.| | PubMed
- Contemporary Management of Hepatic Cyst Disease: Techniques and Outcomes at a Tertiary Hepatobiliary Center.| | PubMed
- Synchronous Versus Metachronous Colorectal Liver Metastasis Yields Similar Survival in Modern Era.| | PubMed
- A rare presentation of hepatolithiasis in an adolescent patient: A case report.| | PubMed
- Ampullary stenosis and choledocholithiasis post Roux-En-Y gastric bypass: challenges of biliary access and intervention.| | PubMed
- A novel stratification of mesenteric mass involvement as a predictor of challenging mesenteric lymph node dissection by minimally invasive approach for ileal neuroendocrine tumors.| | PubMed
- Residual tumor volume discriminates prognosis after surgery for neuroendocrine liver metastasis.| | PubMed
- Prognostic impact of a large mesenteric mass >2 cm in ileal neuroendocrine tumors.| | PubMed
- Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.| | PubMed
- Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization?| | PubMed
- Evaluation of an abbreviated screening MRI protocol for patients at risk for hepatocellular carcinoma.| | PubMed
- Change in Liver Imaging Reporting and Data System Characterization of Focal Liver Lesions Using Gadoxetate Disodium Magnetic Resonance Imaging Compared With Contrast-Enhanced Computed Tomography.| | PubMed
- Multiple arterial phase MRI of arterial hypervascular hepatic lesions: improved arterial phase capture and lesion enhancement.| | PubMed
- Imaging Hepatocellular Carcinoma With 68Ga-Citrate PET: First Clinical Experience.| | PubMed
- Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy?| | PubMed
- In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis.| | PubMed
- Management of Postoperative Hepatic Failure.| | PubMed
- Correcting for respiratory motion in liver PET/MRI: preliminary evaluation of the utility of bellows and navigated hepatobiliary phase imaging.| | PubMed
- The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.| | PubMed
- Impact of pre-operative positron emission tomography in gallbladder cancer.| | PubMed
- Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinoma.| | PubMed
- The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.| | PubMed
- The TGR5 receptor mediates bile acid-induced itch and analgesia.| | PubMed
- Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.| | PubMed
- The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.| | PubMed
- Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract.| | PubMed
- Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity.| | PubMed
- Visual vignette. What is the diagnosis? Insulin-secreting tumor.| | PubMed
- Laparoscopic treatment of liver tumours using a two-needle probe bipolar radiofrequency ablation device.| | PubMed
- Hepatic surgery at a VA tertiary medical center: lessons learned.| | PubMed
- Periprocedural complications by Child-Pugh class in patients undergoing transcatheter arterial embolization or chemoembolization to treat unresectable hepatocellular carcinoma at a VA medical center.| | PubMed
- Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels.| | PubMed
- Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.| | PubMed
- Hemorrhagic cholecystitis.| | PubMed
- Giant mesenteric cystic lymphangioma presenting with abdominal pain and masquerading as a gynecologic malignancy.| | PubMed
- Reversible surgical model of biliary inflammation and obstructive jaundice in mice.| | PubMed
- Abdominal actinomycosis after laparoscopic cholecystectomy: a rare complication of bile spillage.| | PubMed
- Perforated ulcer mimicking a spontaneous pneumothorax in a patient with congenital diaphragmatic hernia.| | PubMed
- Caudate split for open and laparoscopic liver resections.| | PubMed
- Basal cell carcinoma does metastasize.| | PubMed
- Implementation of a multidisciplinary treatment team for hepatocellular cancer at a Veterans Affairs Medical Center improves survival.| | PubMed
- 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer.| | PubMed
- Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder.| | PubMed
- Role of calcitonin receptor-like receptor in colonic motility and inflammation.| | PubMed
- Bipolar pulse coagulation for resection of the cirrhotic liver.| | PubMed
- Recurrent invasive intraductal papillary mucinous carcinoma of the pancreas mimicking pott disease: review of the literature.| | PubMed
- Clinical and pathologic features of proximal biliary strictures masquerading as hilar cholangiocarcinoma.| | PubMed
- The missing thyroid.| | PubMed
- Retrocardiac parathyroid tumor: a rare mediastinal site.| | PubMed
- Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade.| | PubMed
- Role of laparoscopy in the evaluation of biliary tract cancer.| | PubMed
- Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase.| | PubMed
- Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.| | PubMed
- The relationship between hospital volume and outcomes of hepatic resection for hepatocellular carcinoma.| | PubMed
- Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq/11, G-protein receptor kinase-2/3, and beta-arrestin-1/2.| | PubMed
- Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.| | PubMed
- A hospital's annual rate of esophagectomy influences the operative mortality rate.| | PubMed
- Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.| | PubMed
- Recent advances. General surgery.| | PubMed
- Heterogeneity of P2u- and P2y-purinergic receptor regulation of phospholipases in MDCK cells.| | PubMed