University of California San Francisco

Liang You - 144x
Liang
You
PhD

Professor of Surgery
Division of Cardiothoracic Surgery
Thoracic Oncology Laboratory

Address

2340 Sutter Street, #N221
San Francisco, CA 94115
United States

Email: [email protected]
Phone: 415-476-6906
Fax: 415-502-6799

Biography

Dr. Liang You received his M.D. in 1987 from the Jinzhou Medical College in China and his Ph.D. in pathology from the Medical College of Ohio in 1994. He began work at UCSF in the thoracic oncology laboratory after work at the National Cancer Institute. At UCSF, Dr. You has made a significant impact on lung cancer and mesothelioma research. Most notably, he has been been instrumental in helping Dr. David Jablons mold a fledgling research effort into a thriving molecular genomics laboratory, an integral part of the Comprehensive Cancer Center and nationally recognized.

In November 2007, Dr. You was presented with the David Jablons "Asclepios" Award by the Bonnie J. Addario Lung Cancer Foundation for his pioneering research.

Education

Institution Degree Dept or School End Date
University of California, San Francisco Clinical Fellowship

Program Affiliations

  • Thoracic Oncology Program
  • Thoracic Oncology Laboratory
  • UCSF Helen Diller Family Comprehensive Cancer Center

Grants and Funding

  • The Role of Cul4A in Genome Stability and Cancer Development | NIH | 2010-07-09 - 2017-05-31 | Role: Principal Investigator

Research Narrative

Dr. You has been a creative and dynamic force in the lab and his work has led to numerous discoveries. He helped demonstrate the relationship of p14ARF tumor suppressor deletions to the p53 pathway in mesothelioma and the effects of oncolytic viruses upon these tumors. He also discovered several novel mechanisms for the activation of upstream WNT pathways.

Dr. You has helped identify several novel biomarkers and therapeutic targets in lung cancer and mesothelioma. He and his colleagues demonstrated overexpression of Dishevelled-3 and silencing of SFRP-2, SOCS-3 and WIF-1 through promoter methylation. Dr. You and chemist Dr. Naoaki Fujii developed a small molecule Wnt pathway inhibitor, FJ9, that disrupts the interaction between the Frizzled receptor and Dishevelled, a Wnt signal transducer.

Dr. You is currently investigating the use of recombinant human WIF-1 protein as a cancer therapy and seeking out new therapeutic targets and novel interventions. 

Research Interests

  • Human cancer genetics and epigenetics
  • Wnt Signaling Pathway
  • Akt Signaling Pathway
  • Lung cancer and mesothelioma
  • Small molecules, antibodies and recombinant proteins
  • Molecular analysis on matched normal/tumor tissues

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 100
  1. A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells.
    Dai Y, Kyoyama H, Yang YL, Wang Y, Liu S, Wang Y, Mao JH, Xu Z, Uematsu K, Jablons DM, You L| | PubMed
  2. The Crosstalk between Src and Hippo/YAP Signaling Pathways in Non-Small Cell Lung Cancer (NSCLC).
    Hsu PC, Yang CT, Jablons DM, You L| | PubMed
  3. Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells.
    Miao J, Kyoyama H, Liu L, Chan G, Wang Y, Urisman A, Yang YL, Liu S, Xu Z, Bin H, Li H, Jablons DM, You L| | PubMed
  4. Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC).
    Hsu PC, Jablons DM, Yang CT, You L| | PubMed
  5. The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.
    Agnew C, Liu L, Liu S, Xu W, You L, Yeung W, Kannan N, Jablons D, Jura N| | PubMed
  6. Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model.
    Hsu PC, Tian B, Yang YL, Wang YC, Liu S, Urisman A, Yang CT, Xu Z, Jablons DM, You L| | PubMed
  7. Cul4A Modulates Invasion and Metastasis of Lung Cancer Through Regulation of ANXA10.
    Hung MS, Chen YC, Lin P, Li YC, Hsu CC, Lung JH, You L, Xu Z, Mao JH, Jablons DM, Yang CT| | PubMed
  8. The Role of Yes-Associated Protein (YAP) in Regulating Programmed Death-Ligand 1 (PD-L1) in Thoracic Cancer.
    Hsu PC, Yang CT, Jablons DM, You L| | PubMed
  9. Inhibition of yes-associated protein down-regulates PD-L1 (CD274) expression in human malignant pleural mesothelioma.
    Hsu PC, Miao J, Wang YC, Zhang WQ, Yang YL, Wang CW, Yang CT, Huang Z, You J, Xu Z, Jablons DM, You L| | PubMed
  10. Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model.
    Hsu PC, Miao J, Huang Z, Yang YL, Xu Z, You J, Dai Y, Yeh CC, Chan G, Liu S, Urisman A, Yang CT, Jablons DM, You L| | PubMed
  11. YAP regulates PD-L1 expression in human NSCLC cells.
    Miao J, Hsu PC, Yang YL, Xu Z, Dai Y, Wang Y, Chan G, Huang Z, Hu B, Li H, Jablons DM, You L| | PubMed
  12. Hippo pathway in lung development.
    Dai Y, Jablons D, You L| | PubMed
  13. Drug development against the hippo pathway in mesothelioma.
    Woodard GA, Yang YL, You L, Jablons DM| | PubMed
  14. DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma.
    Wang H, Dai YY, Zhang WQ, Hsu PC, Yang YL, Wang YC, Chan G, Au A, Xu ZD, Jiang SJ, Wang W, Jablons DM, You L| | PubMed
  15. Targeting YAP in malignant pleural mesothelioma.
    Zhang WQ, Dai YY, Hsu PC, Wang H, Cheng L, Yang YL, Wang YC, Xu ZD, Liu S, Chan G, Hu B, Li H, Jablons DM, You L| | PubMed
  16. YAP1 regulates ABCG2 and cancer cell side population in human lung cancer cells.
    Dai Y, Liu S, Zhang WQ, Yang YL, Hang P, Wang H, Cheng L, Hsu PC, Wang YC, Xu Z, Jablons DM, You L| | PubMed
  17. YAP promotes erlotinib resistance in human non-small cell lung cancer cells.
    Hsu PC, You B, Yang YL, Zhang WQ, Wang YC, Xu Z, Dai Y, Liu S, Yang CT, Li H, Hu B, Jablons DM, You L| | PubMed
  18. Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells.
    Hung MS, Chen IC, You L, Jablons DM, Li YC, Mao JH, Xu Z, Lung JH, Yang CT, Liu ST| | PubMed
  19. Knockdown of Cul4A increases chemosensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells.
    Hung MS, Chen IC, You L, Jablons DM, Li YC, Mao JH, Xu Z, Hsieh MJ, Lin YC, Yang CT, Liu ST, Tsai YH| | PubMed
  20. Cul4A overexpression associated with Gli1 expression in malignant pleural mesothelioma.
    Yang YL, Ni J, Hsu PC, Mao JH, Hsieh D, Xu A, Chan G, Au A, Xu Z, Jablons DM, You L| | PubMed
  21. Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene.
    Wang Y, Xu Z, Mao JH, Hung MS, Hsieh D, Au A, Jablons DM, You L| | PubMed
  22. Genistein Suppresses Growth of Human Uterine Sarcoma Cell Lines via Multiple Mechanisms.
    Yeh CC, Fan Y, Jiang L, Yang YL, He B, You L, Mann M| | PubMed
  23. PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer.
    Wang Y, Xu Z, Mao JH, Hsieh D, Au A, Jablons DM, Li H, You L| | PubMed
  24. Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells.
    You B, Yang YL, Xu Z, Dai Y, Liu S, Mao JH, Tetsu O, Li H, Jablons DM, You L| | PubMed
  25. CK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells.
    Zhang S, Yang YL, Wang Y, You B, Dai Y, Chan G, Hsieh D, Kim IJ, Fang LT, Au A, Stoppler HJ, Xu Z, Jablons DM, You L| | PubMed
  26. An alternative way to initiate Notch1 signaling in non-small cell lung cancer.
    Yang YL, Jablons D, You L| | PubMed
  27. Lung tumourigenesis in a conditional Cul4A transgenic mouse model.
    Yang YL, Hung MS, Wang Y, Ni J, Mao JH, Hsieh D, Au A, Kumar A, Quigley D, Fang LT, Yeh CC, Xu Z, Jablons DM, You L| | PubMed
  28. CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression.
    Wang Y, Wen M, Kwon Y, Xu Y, Liu Y, Zhang P, He X, Wang Q, Huang Y, Jen KY, LaBarge MA, You L, Kogan SC, Gray JW, Mao JH, Wei G| | PubMed
  29. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model.
    Hung MS, Xu Z, Chen Y, Smith E, Mao JH, Hsieh D, Lin YC, Yang CT, Jablons DM, You L| | PubMed
  30. Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2.
    Liu S, Hsieh D, Yang YL, Xu Z, Peto C, Jablons DM, You L| | PubMed
  31. Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer.
    Bravo DT, Yang YL, Kuchenbecker K, Hung MS, Xu Z, Jablons DM, You L| | PubMed
  32. Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells.
    Zhang S, Long H, Yang YL, Wang Y, Hsieh D, Li W, Au A, Stoppler HJ, Xu Z, Jablons DM, You L| | PubMed
  33. Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells.
    Zhang S, Wang Y, Mao JH, Hsieh D, Kim IJ, Hu LM, Xu Z, Long H, Jablons DM, You L| | PubMed
  34. The expression of Dishevelled-3 and glutamine metabolism in malignant pleural mesothelioma.
    Li T, Hou SC, Mao JH, Wang YC, Lu XD, Tan JL, You B, Liu YP, Ni J, Au A, Jablons DM, Xu Z, You L| | PubMed
  35. Transgenic mice for cre-inducible overexpression of the Cul4A gene.
    Li T, Hung MS, Wang Y, Mao JH, Tan JL, Jahan K, Roos H, Xu Z, Jablons DM, You L| | PubMed
  36. Cul4A is an oncogene in malignant pleural mesothelioma.
    Hung MS, Mao JH, Xu Z, Yang CT, Yu JS, Harvard C, Lin YC, Bravo DT, Jablons DM, You L| | PubMed
  37. The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma.
    Li T, Li H, Wang Y, Harvard C, Tan JL, Au A, Xu Z, Jablons DM, You L| | PubMed
  38. Adenovirus-mediated SOCS3 gene transfer inhibits the growth and enhances the radiosensitivity of human non-small cell lung cancer cells.
    Lin YC, Lin CK, Tsai YH, Weng HH, Li YC, You L, Chen JK, Jablons DM, Yang CT| | PubMed
  39. Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.
    Hung MS, Lin YC, Mao JH, Kim IJ, Xu Z, Yang CT, Jablons DM, You L| | PubMed
  40. Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells.
    Gao Z, Xu Z, Hung MS, Lin YC, Wang T, Gong M, Zhi X, Jablons DM, You L| | PubMed
  41. Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells.
    Gao Z, Xu Z, Hung MS, Lin YC, Wang T, Gong M, Zhi X, Jablon DM, You L| | PubMed
  42. Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library.
    Hung MS, Xu Z, Lin YC, Mao JH, Yang CT, Chang PJ, Jablons DM, You L| | PubMed
  43. Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis.
    Chou J, Lin YC, Kim J, You L, Xu Z, He B, Jablons DM| | PubMed
  44. Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription.
    You L, Xu Z, Punchihewa C, Jablons DM, Fujii N| | PubMed
  45. Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus.
    Clément G, Guilleret I, He B, Yagui-Beltrán A, Lin YC, You L, Xu Z, Shi Y, Okamoto J, Benhattar J, Jablons D| | PubMed
  46. Targeting the Wnt signaling pathway with dishevelled and cisplatin synergistically suppresses mesothelioma cell growth.
    Uematsu K, Seki N, Seto T, Isoe C, Tsukamoto H, Mikami I, You L, He B, Xu Z, Jablons DM, Eguchi K| | PubMed
  47. Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells.
    Shi Y, He B, Kuchenbecker KM, You L, Xu Z, Mikami I, Yagui-Beltran A, Clement G, Lin YC, Okamoto J, Bravo DT, Jablons DM| | PubMed
  48. Roles of secreted frizzled-related proteins in cancer.
    Shi Y, He B, You L, Jablons DM| | PubMed
  49. Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth.
    Lin YC, You L, Xu Z, He B, Yang CT, Chen JK, Mikami I, Clément G, Shi Y, Kuchenbecker K, Okamoto J, Kashani-Sabet M, Jablons DM| | PubMed
  50. Wnt inhibitory factor inhibits lung cancer cell growth.
    Kim J, You L, Xu Z, Kuchenbecker K, Raz D, He B, Jablons D| | PubMed
  51. An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.
    Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J, Guy RK, Jablons DM| | PubMed
  52. Stathmin is overexpressed in malignant mesothelioma.
    Kim JY, Harvard C, You L, Xu Z, Kuchenbecker K, Baehner R, Jablons D| | PubMed
  53. Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma.
    Batra S, Shi Y, Kuchenbecker KM, He B, Reguart N, Mikami I, You L, Xu Z, Lin YC, Clément G, Jablons DM| | PubMed
  54. Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines.
    Lin YC, You L, Xu Z, He B, Mikami I, Thung E, Chou J, Kuchenbecker K, Kim J, Raz D, Yang CT, Chen JK, Jablons DM| | PubMed
  55. Wnt-1 signal as a potential cancer therapeutic target.
    You L, Kim J, He B, Xu Z, McCormick F, Jablons DM| | PubMed
  56. The role of Wnt signaling in cancer and stem cells.
    Reguart N, He B, Taron M, You L, Jablons DM, Rosell R| | PubMed
  57. Wnt2 as a new therapeutic target in malignant pleural mesothelioma.
    Mazieres J, You L, He B, Xu Z, Twogood S, Lee AY, Reguart N, Batra S, Mikami I, Jablons DM| | PubMed
  58. Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis.
    Mazieres J, You L, He B, Xu Z, Lee AY, Mikami I, McCormick F, Jablons DM| | PubMed
  59. Wnt signaling in stem cells and non-small-cell lung cancer.
    He B, Barg RN, You L, Xu Z, Reguart N, Mikami I, Batra S, Rosell R, Jablons DM| | PubMed
  60. Efficacy of Wnt-1 monoclonal antibody in sarcoma cells.
    Mikami I, You L, He B, Xu Z, Batra S, Lee AY, Mazieres J, Reguart N, Uematsu K, Koizumi K, Jablons DM| | PubMed
  61. Wnt signaling in lung cancer.
    Mazieres J, He B, You L, Xu Z, Jablons DM| | PubMed
  62. Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations.
    He B, Reguart N, You L, Mazieres J, Xu Z, Lee AY, Mikami I, McCormick F, Jablons DM| | PubMed
  63. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells.
    He B, Lee AY, Dadfarmay S, You L, Xu Z, Reguart N, Mazieres J, Mikami I, McCormick F, Jablons DM| | PubMed
  64. Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma.
    Lee AY, He B, You L, Xu Z, Mazieres J, Reguart N, Mikami I, Batra S, Jablons DM| | PubMed
  65. Cloning and characterization of the promoter of human Wnt inhibitory factor-1.
    Reguart N, He B, Xu Z, You L, Lee AY, Mazieres J, Mikami I, Batra S, Rosell R, McCormick F, Jablons DM| | PubMed
  66. Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma.
    Lee AY, He B, You L, Dadfarmay S, Xu Z, Mazieres J, Mikami I, McCormick F, Jablons DM| | PubMed
  67. Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells.
    You L, He B, Xu Z, Uematsu K, Mazieres J, Mikami I, Reguart N, Moody TW, Kitajewski J, McCormick F, Jablons DM| | PubMed
  68. An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.
    You L, He B, Xu Z, Uematsu K, Mazieres J, Fujii N, Mikami I, Reguart N, McIntosh JK, Kashani-Sabet M, McCormick F, Jablons DM| | PubMed
  69. Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts.
    Beseth BD, Cameron RB, Leland P, You L, Varricchio F, Kreitman RJ, Maki RA, Jablons DM, Husain SR, Puri RK| | PubMed
  70. Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer.
    Mazieres J, He B, You L, Xu Z, Lee AY, Mikami I, Reguart N, Rosell R, McCormick F, Jablons DM| | PubMed
  71. Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells.
    You L, He B, Uematsu K, Xu Z, Mazieres J, Lee A, McCormick F, Jablons DM| | PubMed
  72. Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer.
    He B, You L, Xu Z, Mazieres J, Lee AY, Jablons DM| | PubMed
  73. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells.
    He B, You L, Uematsu K, Xu Z, Lee AY, Matsangou M, McCormick F, Jablons DM| | PubMed
  74. Future directions: oncolytic viruses.
    You L, He B, Xu Z, McCormick F, Jablons DM| | PubMed
  75. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer.
    He B, You L, Uematsu K, Zang K, Xu Z, Lee AY, Costello JF, McCormick F, Jablons DM| | PubMed
  76. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression.
    Uematsu K, He B, You L, Xu Z, McCormick F, Jablons DM| | PubMed
  77. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin.
    Uematsu K, Kanazawa S, You L, He B, Xu Z, Li K, Peterlin BM, McCormick F, Jablons DM| | PubMed
  78. Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q.
    Jensen RH, Tiirikainen M, You L, Ginzinger D, He B, Uematsu K, Xu Z, Treseler P, McCormick F, Jablons DM| | PubMed
  79. Cloning and characterization of a functional promoter of the human SOCS-3 gene.
    He B, You L, Uematsu K, Matsangou M, Xu Z, He M, McCormick F, Jablons DM| | PubMed
  80. A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14ARF and p16INK4A) in human mesothelioma cells.
    Yang CT, You L, Lin YC, Lin CL, Mccormick F, Jablons DM| | PubMed
  81. Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides.
    Xia C, Xu Z, Yuan X, Uematsu K, You L, Li K, Li L, McCormick F, Jablons DM| | PubMed
  82. p14(ARF) modulates the cytolytic effect of ONYX-015 in mesothelioma cells with wild-type p53.
    Yang CT, You L, Uematsu K, Yeh CC, McCormick F, Jablons DM| | PubMed
  83. A multicenter evaluation of assays for detection of SV40 DNA and results in masked mesothelioma specimens.
    Strickler HD, International SV40 Working Group| | PubMed
  84. Indomethacin reduces lung adenoma number in A/J mice.
    Moody TW, Leyton J, Zakowicz H, Hida T, Kang Y, Jakowlew S, You L, Ozbun L, Zia H, Youngberg J, Malkinson A| | PubMed
  85. Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily.
    Ozbun LL, You L, Kiang S, Angdisen J, Martinez A, Jakowlew SB| | PubMed
  86. Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells.
    Casibang M, Purdom S, Jakowlew S, Neckers L, Zia F, Ben-Av P, Hla T, You L, Jablons DM, Moody TW| | PubMed
  87. Stage II (N1) lung cancer.
    Choy O, Jahan T, Roach M, You L, Jablons D| | PubMed
  88. Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells.
    Yang CT, You L, Yeh CC, Chang JW, Zhang F, McCormick F, Jablons DM| | PubMed
  89. ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients.
    You L, Yang CT, Jablons DM| | PubMed
  90. Transforming growth factor-beta expression in mouse lung carcinogenesis.
    Jakowlew SB, Moody TW, You L, Mariano JM| | PubMed
  91. Reduction in transforming growth factor-beta type II receptor in mouse lung carcinogenesis.
    Jakowlew SB, Moody TW, You L, Mariano JM| | PubMed
  92. Identification of early growth response gene-1 (Egr-1) as a phorbol myristate acetate-induced gene in lung cancer cells by differential mRNA display.
    You L, Jakowlew SB| | PubMed
  93. Differential regulation of protease and extracellular matrix protein expression by transforming growth factor-beta 1 in non-small cell lung cancer cells and normal human bronchial epithelial cells.
    Jakowlew SB, Mariano JM, You L, Mathias A| | PubMed
  94. Effects of transforming growth factor-beta 1 and phorbol ester on PAI-1 and PA genes in human lung cells.
    Jakowlew SB, Mariano JM, You L| | PubMed
  95. Carcinogenicity, DNA adduct formation and K-ras activation by 7H-dibenzo[c,g]carbazole in strain A/J mouse lung.
    Warshawsky D, Talaska G, Jaeger M, Collins T, Galati A, You L, Stoner G| | PubMed
  96. Frameshift mutation in codon 176 of the p53 gene in rat esophageal epithelial cells transformed by benzo[a]pyrene dihydrodiol.
    Wang D, You L, Sneddon J, Cheng SJ, Jamasbi R, Stoner GD| | PubMed
  97. Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung.
    You L, Wang D, Galati AJ, Ross JA, Mass MJ, Nelson GB, Wilson KH, Amin S, Stoner JC, Nesnow S| | PubMed
  98. Allele-specific activation and expression of the K-ras gene in hybrid mouse lung tumors induced by chemical carcinogens.
    Chen B, You L, Wang Y, Stoner GD, You M| | PubMed
  99. Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids.
    You M, Wang Y, Stoner G, You L, Maronpot R, Reynolds SH, Anderson M| | PubMed
  100. Activation of protooncogenes in mouse lung tumors.
    You M, Wang Y, Lineen A, Stoner GD, You LA, Maronpot RR, Anderson MW| | PubMed