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Biao He, Ph.D.

Biao He, Ph.D.

Thoracic Oncology Program
Division of Adult Cardiothoracic Surgery

Contact Information

2340 Sutter Street N-222, Box 1724
University of California, San Francisco
San Francisco, CA 94143-1724
(415) 476-6907 Phone
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  • 1988-93, Tsinghua University, Beijing, China B.Sc.  Biochemistry
  • 1993-95, Tsinghua University, Beijing, China M.S.  Biochemistry
  • 1995-01, University of Virginia Ph.D.  Molecular Genetics
  • 1992 Guanghua Scholarship Tsinghua University, Beijing, China
  • 1995 Hua Luogeng Memorial Fellowship Tsinghua University, Beijing, China
  • 1995-1996 Fellowship
  • 2001-02, Postdoctoral Researcher, UCSF Helen Diller Family Comprehensive Cancer Center,
  • 2002-04, Assistant Research Molecular Biologist, UCSF Helen Diller Family Comprehensive Cancer Center
  • Thoracic Oncology Program
  • Thoracic Oncology Laboratory
  • UCSF Helen Diller Family Comprehensive Cancer Center
  • UCSF Department of Surgery
  • Epigenetics
  • Isolation of lung cancer stem cells
  • Microarrays and high throughput scanning
  • Novel targeted therapies for lung & colon cancer, mesothelioma
  • Small molecule inhibitors
  • Stem cell biology, cancer stem cells
  • Wnt and Hedgehog signaling

Dr. Biao He is a molecular geneticist and senior scientist in the Thoracic Oncology Laboratory at the UCSF Helen Diller Family Comprehensive Cancer Center. Dr. He graduated from the prestigious Tsinghua University in Beijing, China with a B.S. and M.S. in Biochemistry. He later received a Ph.D. from the University of Virginia in molecular genetics. Dr. He was recruited to the Thoracic Oncology Laboratory based on his extensive knowledge of the Wnt signaling pathway and RNA interference (RNAi). He began as a postdoctoral fellow and soon advanced to the position of Assistant Research Molecular Biologist. In 2004, Dr. He joined the UCSF faculty.

Biao He With Eqiupment

Dr. He has been the author of numerous peer-reviewed papers. His current research is focused on the molecular mechanisms of non-small cell lung cancer and mesothelioma. He is also developing targeted therapies against these diseases. Dr. He has also been the recipient of numerous awards including the Hua Luogeng Memorial Fellowship, Eileen Ludwig Award for Thoracic Oncology Research, and Barbara Isackson Award for Thoracic Oncology Research.

Dr. He's current research focuses on the molecular mechanisms in tumorigenesis of lung cancer and malignant mesothelioma, and the development of targeted therapies for these cancer types. Dr. He has been a PI and co-PI of a number of research projects funded by NIH and Foundations, such as, identification and validation of novel potential therapeutic targets in lung cancer and mesothelioma; role of inflammation and epigenetic alterations in lung carcinogenesis; elucidation of novel molecular mechanisms involving Wnt and Hedgehog signal pathways in carcinogenesis; identification and validation of prognostic and predictive markers; and development of small molecule inhibitors of signaling pathways as potential leads for targeted cancer therapies.

Most recent publications from a total of 57
  1. Tolani B, Hoang NT, Acevedo LA, Giroux Leprieur E, Li H, He B, Jablons DM. Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog. Oncotarget. 2018 03 06; 9(18):14311-14323. View in PubMed
  2. Tolani B, Acevedo LA, Hoang NT, He B. Heterogeneous Contributing Factors in MPM Disease Development and Progression: Biological Advances and Clinical Implications. Int J Mol Sci. 2018 Jan 13; 19(1). View in PubMed
  3. Giroux Leprieur E, Tolani B, Li H, Leguay F, Hoang NT, Acevedo LA, Jin JQ, Tseng HH, Yue D, Kim IJ, Wislez M, Wang C, Jablons DM, He B. Membrane-bound full-length Sonic Hedgehog identifies cancer stem cells in human non-small cell lung cancer. Oncotarget. 2017 11 28; 8(61):103744-103757. View in PubMed
  4. Li H, Yue D, Jin JQ, Woodard GA, Tolani B, Luh TM, Giroux-Leprieur E, Mo M, Chen Z, Che J, Zhang Z, Zhou Y, Wang L, Hao X, Jablons D, Wang C, He B. Gli promotes epithelial-mesenchymal transition in human lung adenocarcinomas. Oncotarget. 2016 Dec 06; 7(49):80415-80425. View in PubMed
  5. Xu Y, Ding VW, Zhang H, Zhang X, Jablons D, He B. Spotlight on afatinib and its potential in the treatment of squamous cell lung cancer: the evidence so far. Ther Clin Risk Manag. 2016; 12:807-16. View in PubMed
  6. Yue D, Li H, Che J, Zhang Y, Tolani B, Mo M, Zhang H, Zheng Q, Yang Y, Cheng R, Jin JQ, Luh TW, Yang C, Tseng HH, Giroux-Leprieur E, Woodard GA, Hao X, Wang C, Jablons DM, He B. EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas. PLoS One. 2015; 10(7):e0132134. View in PubMed
  7. Yeh CC, Fan Y, Jiang L, Yang YL, He B, You L, Mann M. Genistein Suppresses Growth of Human Uterine Sarcoma Cell Lines via Multiple Mechanisms. Anticancer Res. 2015 Jun; 35(6):3167-73. View in PubMed
  8. Hirata T, Zheng Q, Chen Z, Kinoshita H, Okamoto J, Kratz J, Li H, Lui N, Do H, Cheng T, Tseng HH, Koizumi K, Shimizu K, Zhou HM, Jablons D, He B. Wnt7A is a putative prognostic and chemosensitivity marker in human malignant pleural mesothelioma. Oncol Rep. 2015 Apr; 33(4):2052-60. View in PubMed
  9. Giroux Leprieur E, Hirata T, Mo M, Chen Z, Okamoto J, Clement G, Li H, Wislez M, Jablons DM, He B. The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma. Lung Cancer. 2014 Sep; 85(3):465-71. View in PubMed
  10. Kratz JR, Tham PT, Mulvihill MS, Ziaei F, Ray MR, Hurst JW, Segal MR, Berryman DM, Chu W, He B, Jablons DM, Mann MJ. Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer. Diagn Mol Pathol. 2013 Jun; 22(2):65-9. View in PubMed
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