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Thoracic Oncology Program »  Meet the Team »  Medical Oncologists »  Collin Blakely, M.D., Ph.D.
Collin Blakely, M.D., Ph.D.

Collin Blakely, M.D., Ph.D.

Assistant Clinical Professor
Division of Hematology/Oncology
Department of Medicine

Contact Information

(415) 885-3882  Patients & Clinic 
(415) 353-9525  Fax
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University of Washington, B.S. 1997
University of Pennsylvania, M.D., Ph.D. 2007

  • Hospital of the University of Pennsylvania, Internship in Internal Medicine, 2007-2008

  • Hospital of the University of Pennsylvania, Residency in Internal Medicine, 2008-2009
  • UCSF, Fellowship in Medical Oncology, 2009-2011
  • Postdoctoral Fellow - UCSF, Lisa Coussens Laboratory, 2010-2012

  • Postdoctoral Fellow - UCSF, Trever Bivona Laboratory, 2012-2014
  • Non-small cell lung cancer
  • Small cell lung cancer
  • ALK-rearranged lung cancer
  • EGFR-mutant lung cancer
  • Mechanisms of resistance to targeted therapies
  • ROS1-rearranged lung cancer

Collin is a medical oncologist specializing in the treatment of lung cancer. He received his Bachelor of Science degree in Molecular and Cellular Biology from the University of Washington and attended the Perelman School of Medicine at the University of Pennsylvania in the Medical Scientist Training Program. He completed his Internal Medicine residency at the Hospital of the University of Pennsylvania and trained as a clinical fellow in Medical Oncology at UCSF. His research focuses on understanding the cellular and molecular mechanisms underlying lung cancer resistance to EGFR-targeted therapies. His goal is to translate laboratory-based findings into new treatments for lung cancer patients.

  Award  
  Confired By    
  Date    
  • Damon Runyon Clinical Investigator Award
  • Damon Runyon Cancer Research Foundation
  • 2018 - 2021
  • V Scholar Award
  • V Foundation
  • 2018 - 2020
  • Clinical Scientist Award
  • Doris Duke Charitable Foundation
  • 2018 - 2012
  • AACR BioOncology Fellowship
  • AACR
  • 2014 - 2016
  • Legacy Award
  • Uniting Against Lung Cancer
  • 2014 - 2016
  • Research Grant
  • Bonnie J. Addario Lung Cancer Foundation
  • 2013
  • The primary focus of my research is to translate laboratory-based findings into novel investigator sponsored trials that aim to assess the safety and efficacy of rationally designed targeted therapies for lung cancer patients.

    My goals are to: 1) define how TKI resistance pathways evolve at the tumor genome, transcriptome and molecular signaling levels within lung cancers and to translate these findings into novel prognostic and predictive biomarkers that may predict TKI resistance before it occurs; 2) develop investigator sponsored clinical trials to test rational companion therapies that can prevent, delay, or overcome TKI resistance, 3) develop investigator sponsored clinical trials to target recently identified oncogenic pathways, outside of EGFR and ALK, that drive NSCLC; and 4) establish a cohort of patient-derived xenograft (PDX) mice to foster research that aims to further understand the molecular mechanisms of response and resistance to TKI therapies in lung cancer

    Data provided by UCSF Profiles, powered by CTSI
    MOST RECENT PUBLICATIONS FROM A TOTAL OF 41
    Data provided by UCSF Profiles, powered by CTSI
    1. Ali M, Lu M, Ang HX, Soderquist RS, Eyler CE, Hutchinson HM, Glass C, Bassil CF, Lopez OM, Kerr DL, Falcon CJ, Yu HA, Hata AN, Blakely CM, McCoach CE, Bivona TG, Wood KC. Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells. Sci Transl Med. 2022 Mar 30; 14(638):eabc7480. View in PubMed
    2. Ganti AKP, Loo BW, Bassetti M, Blakely C, Chiang A, D'Amico TA, D'Avella C, Dowlati A, Downey RJ, Edelman M, Florsheim C, Gold KA, Goldman JW, Grecula JC, Hann C, Iams W, Iyengar P, Kelly K, Khalil M, Koczywas M, Merritt RE, Mohindra N, Molina J, Moran C, Pokharel S, Puri S, Qin A, Rusthoven C, Sands J, Santana-Davila R, Shafique M, Waqar SN, Gregory KM, Hughes M. Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021 12; 19(12):1441-1464. View in PubMed
    3. Barbosa Rabago D, Blakely CM, Haderk F, Bivona TG. Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids. J Vis Exp. 2021 Nov 22; (177). View in PubMed
    4. Wong ML, Shi Y, Smith AK, Miaskowski C, Boscardin WJ, Cohen HJ, Lam V, Mazor M, Metzger L, Presley CJ, Williams GR, Loh KP, Ursem CJ, Friedlander TW, Blakely CM, Gubens MA, Allen G, Shumay D, Walter LC. Changes in older adults' life space during lung cancer treatment: A mixed methods cohort study. J Am Geriatr Soc. 2022 01; 70(1):136-149. View in PubMed
    5. Woodard GA, Kratz JR, Haro G, Gubens MA, Blakely CM, Jones KD, Mann MJ, Jablons DM. Molecular Risk Stratification is Independent of EGFR Mutation Status in Identifying Early-Stage Non-Squamous Non-Small Cell Lung Cancer Patients at Risk for Recurrence and Likely to Benefit From Adjuvant Chemotherapy. Clin Lung Cancer. 2021 11; 22(6):587-595. View in PubMed
    6. View All Publications

     

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